Strategies for Antimicrobial Peptides Immobilization on Surfaces to Prevent Biofilm Growth on Biomedical Devices - Chimie ParisTech Accéder directement au contenu
Article Dans Une Revue Antibiotics Année : 2022

Strategies for Antimicrobial Peptides Immobilization on Surfaces to Prevent Biofilm Growth on Biomedical Devices

Résumé

Nosocomial and medical device-induced biofilm infections affect millions of lives and urgently require innovative preventive approaches. These pathologies have led to the development of numerous antimicrobial strategies, an emergent topic involving both natural and synthetic routes, among which some are currently under testing for clinical approval and use. Antimicrobial peptides (AMPs) are ideal candidates for this fight. Therefore, the strategies involving surface functionalization with AMPs to prevent bacterial attachment/biofilms formation have experienced a tremendous development over the last decade. In this review, we describe the different mechanisms of action by which AMPs prevent bacterial adhesion and/or biofilm formation to better address their potential as anti-infective agents. We additionally analyze AMP immobilization techniques on a variety of materials, with a focus on biomedical applications. Furthermore, we summarize the advances made to date regarding the immobilization strategies of AMPs on various surfaces and their ability to prevent the adhesion of various microorganisms. Progress toward the clinical approval of AMPs in antibiotherapy is also reviewed.

Domaines

Chimie Matériaux
Fichier principal
Vignette du fichier
antibiotics-11-00013-v2.pdf (12.37 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03541402 , version 1 (24-01-2022)

Identifiants

Citer

Mathieu Nicolas, Bruno Beito, Marta Oliveira, Maria Tudela Martins, Bruno Gallas, et al.. Strategies for Antimicrobial Peptides Immobilization on Surfaces to Prevent Biofilm Growth on Biomedical Devices. Antibiotics, 2022, 11 (1), pp.13. ⟨10.3390/antibiotics11010013⟩. ⟨hal-03541402⟩
83 Consultations
102 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More