Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling

Riccardo Rubbiani , Wenyu Wu , Anu Naik , Michele Larocca , Lukas Schneider , Roxane Padrutt , Vipin Babu , Christiane König , Doris Hinger , Caroline Maake , Stefano Ferrari , Gilles Gasser (1) , Bernhard Spingler

1 ENSCP - Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL

Novel tetraplatinated metalloporphyrin-based photosensitizers (PSs) are reported, which show excellent phototoxic indexes up to 5800 against HeLa cells, which is, to the best of our knowledge, the highest value reported for any porphyrin so far. Furthermore, 67 Zn isotope labelling allowed to determine the ratio of zinc to platinum inside the cells by ICP-MS.

Domaines: Chimie thérapeutique

Riccardo Rubbiani, Wenyu Wu, Anu Naik, Michele Larocca, Lukas Schneider, et al.. Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling. Chemical Communications, 2020, ⟨10.1039/D0CC05196A⟩. ⟨hal-02973034⟩