Mid-infrared spectroscopy of serum, a promising non-invasive method to assess prognosis in patients with ascites and cirrhosis

Maëna Le Corvec (1, 2) , Caroline Jezequel (3) , Valérie Monbet (4, 5) , Nadia Fatih (1, 6) , Frédéric Charpentier (1) , Hugues Tariel (1) , Catherine Boussard-Plédel (7) , Bruno Bureau (7) , Olivier Loréal (6) , Olivier Sire (8) , Edouard Bardou-Jacquet (6)

1 DIAFIR
2 IRDL - Institut de Recherche Dupuy de Lôme
3 Service des Maladies de l'Appareil Digestif [CHU Rennes]
4 ASPI - Applications of interacting particle systems to statistics
5 IRMAR - Institut de Recherche Mathématique de Rennes
6 NuMeCan - Nutrition, Métabolismes et Cancer
7 ISCR - Institut des Sciences Chimiques de Rennes
8 LIMATB - Laboratoire d'Ingénierie des Matériaux de Bretagne

Background & aims:Prognostic tests are critical in the management of patients with cirrhosis and ascites. Biological tests or scores perform poorly in that situation. Mid-infrared fibre evanescent wave spectroscopy (MIR-FEWS) which allows for global serum metabolic profiling may provide more relevant information by measuring a wider range of metabolic parameters in serum. Here we present the accuracy of a MIR-FEWS based predictive model for the prognosis of 6 months survival in patients with ascites and cirrhosis.Methods: Patients with ascites were prospectively included and followed up for 6 months. MIR-FEWS spectra were measured in serum samples. The most informative spectral variables obtained by MIR-FEWS were selected by FADA algorithm and then used to build the MIR model. Accuracy of this model was assessed by ROC curves and 90%/10% Monte Carlo cross-validation. MIR model accuracy for 6 months survival was compared to that of the Child-Pugh and MELD scores.Results: 119 patients were included. The mean age was 57.36±13.70, the MELD score was 16.32±6.26, and the Child-Pugh score was 9.5±1.83. During follow-up, 23 patients died (20%). The MIR model had an AUROC for 6 months mortality of 0.90 (CI95: 0.88–0.91), the MELD 0.77 (CI95: 0.66–0.89) and Child-Pugh 0.76 (CI95: 0.66–0.88). MELD and Child-Pugh AUROCs were significantly lower than that of the MIR model (p = 0.02 and p = 0.02 respectively). Multivariate logistic regression analysis showed that MELD (p<0.05, OR:0.86;CI95:0.76–0.97), Beta blockers (p = 0.036;OR:0.20;CI95:0.04–0.90), and the MIR model (p<0.001; OR:0.50; CI95:0.37–0.66), were significantly associated with 6 months mortality.Conclusions: In this pilot study MIR-FEWS more accurately assess the 6-month prognosis of patients with ascites and cirrhosis than the MELD or Child-Pugh scores. These promising results, if confirmed by a larger study, suggest that mid infrared spectroscopy could be helpful in the management of these patients.

Mots clés: decompensated cirrhosis; FTIR spectroscopy; survival; hepatic-encephalopathy; breast-cancer; hepatocellular-carcinoma; infrared-spectroscopy; stage liver-disease; model; diagnosis

Domaines: Statistiques [math.ST]

Maëna Le Corvec, Caroline Jezequel, Valérie Monbet, Nadia Fatih, Frédéric Charpentier, et al.. Mid-infrared spectroscopy of serum, a promising non-invasive method to assess prognosis in patients with ascites and cirrhosis. PLoS ONE, 2017, 12 (10), pp.e0185997. ⟨10.1371/journal.pone.0185997⟩. ⟨hal-01625051⟩