Skip to Main content Skip to Navigation
Journal articles

Diagnosis, risk factors and management of diabetes mellitus in HIV-infected persons in France: A real-life setting study

Abstract : Background: Diabetes mellitus (DM) is a major and increasing public health problem that may be underdiagnosed and undertreated among persons living with HIV (PLWH). Objective: To describe the diagnosis, treatment and follow-up of DM among PLWH. Methods: This study was performed inside a monocentric cohort of 1494 PLWH. DM was defined as having a FG ≥126 mg/dL twice or a HbA1c ≥6.5%, or a history of diabetes, or receiving antidiabetic treatment. The first visit mentioning a diagnosis of DM was considered as the baseline visit. Chi-Square or Fisher exact test were used to examine the association between categorical variables and DM, Wilcoxon or Student t-test were used for continuous variables. Results: 156 PLWH with DM were included. Compared to non-diabetic participants, they were more likely to be native of Sub Saharan Africa (31.6% vs. 22.4%, p = 0.027) and older (54.6 vs. 49.9 years, p<0.001), to have a higher BMI (> 25 for 46.1% vs. 35.3%, p = 0.020) and a poorer control of HIV (HIV RNA<50 copies/mL: 80.1% vs. 89.5%, p<0.001). The diagnosis of DM was missed in 37.8% of PLWH, and 47.2% of PLWH treated for DM did not reach a HbA1c<7%. PLWH with DM were more frequently on antihypertensive and/or lipid-lowering medications: 94.2% had a LDL-cholesterol <70 mg/dL and 60.9% had a blood pressure <140/90 mmHg. Conclusion: In a setting of HIV-control, HIV care providers should focus on metabolic issues. The management of DM and associated risk factors is mandatory to prevent cardiovascular disease in PLWH.
Document type :
Journal articles
Complete list of metadata

https://hal.sorbonne-universite.fr/hal-03229613
Contributor : Gestionnaire Hal-Su <>
Submitted on : Wednesday, May 19, 2021 - 9:58:48 AM
Last modification on : Friday, June 11, 2021 - 8:38:03 AM

File

journal.pone.0250676.pdf
Publication funded by an institution

Identifiers

Citation

Isabelle Kousignian, Aurélie Sautereau, Corinne Vigouroux, Agnès Cros, Sandrine Kretz, et al.. Diagnosis, risk factors and management of diabetes mellitus in HIV-infected persons in France: A real-life setting study. PLoS ONE, Public Library of Science, 2021, 16 (5), pp.e0250676. ⟨10.1371/journal.pone.0250676⟩. ⟨hal-03229613⟩

Share

Metrics

Record views

53

Files downloads

22