Discriminate the response of Acute Myeloid Leukemia patients to treatment by using proteomics data and Answer Set Programming - Centre de Recherche en Cancérologie et Immunologie Nantes Angers Accéder directement au contenu
Article Dans Une Revue BMC Bioinformatics Année : 2018

Discriminate the response of Acute Myeloid Leukemia patients to treatment by using proteomics data and Answer Set Programming

Résumé

Background: During the last years, several approaches were applied on biomedical data to detect disease specific proteins and genes in order to better target drugs. It was shown that statistical and machine learning based methods use mainly clinical data and improve later their results by adding omics data. This work proposes a new method to discriminate the response of Acute Myeloid Leukemia (AML) patients to treatment. The proposed approach uses proteomics data and prior regulatory knowledge in the form of networks to predict cancer treatment outcomes by finding out the different Boolean networks specific to each type of response to drugs. To show its effectiveness we evaluate our method on a dataset from the DREAM 9 challenge. Results: The results are encouraging and demonstrate the benefit of our approach to distinguish patient groups with different response to treatment. In particular each treatment response group is characterized by a predictive model in the form of a signaling Boolean network. This model describes regulatory mechanisms which are specific to each response group. The proteins in this model were selected from the complete dataset by imposing optimization constraints that maximize the difference in the logical response of the Boolean network associated to each group of patients given the omic dataset. This mechanistic and predictive model also allow us to classify new patients data into the two different patient response groups. Conclusions: We propose a new method to detect the most relevant proteins for understanding different patient responses upon treatments in order to better target drugs using a Prior Knowledge Network and proteomics data. The results are interesting and show the effectiveness of our method.
Fichier principal
Vignette du fichier
s12859-018-2034-4.pdf (1.88 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-01988426 , version 1 (22-03-2023)

Identifiants

Citer

Lokmane Chebouba, Bertrand Miannay, Dalila Boughaci, Carito Guziolowski. Discriminate the response of Acute Myeloid Leukemia patients to treatment by using proteomics data and Answer Set Programming. BMC Bioinformatics, 2018, 19 (S2), ⟨10.1186/s12859-018-2034-4⟩. ⟨hal-01988426⟩
232 Consultations
12 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More